In an era of limitless data and instant analysis, why are vaccine efficacies for the COVID-recovered omitted in pharma-sponsored studies? And, why aren't our leaders asking questions ?
As a parent of a covid recovered child, I am especially concerned about the potential vaccine mandate for all children in public & private schools in NY (an assembly bill A08378 has been introduced) I have been following your substack closely and wondering if any studies of Covid recovered & vaccinated children are in progress and when might we have more information? I feel at this point in time, I can’t in good conscience allow my child to be vaccinated without any AE data.
Hi there - generally in the same boat as you; I do not know of anything specific, but as with the adult population, I would expect they are doing real-world surveillance and some initial studies will come out in the next month or two. Agree we need much more AE data, and longer follow-up. Best-
You state you are a physician and hope that vaccinated someone previously infected will result in better immunity. Has there ever been a vaccine developed that has been used in those who have already recovered from the same disease? I am not a physician but it is my understanding that vaccines have always been used to provide immunity to those who have not had the disease. The EUA for these vaccines was for active immunization for the prevention of COVID-19 caused by SARS-CoV-2. Only after that narrative failed did the CDC begin to say its real purpose was to prevent severe covid. I would have thought the EUA should have been rescinded.
Thank you for your comment and for reading. Nothing in medicine is absolute . . . and so I am certain there are examples, and I don't purport to know vast expanse of vaccinology. That being said I agree with you that the case for the initial EUA is different than the current rationale, and continues to evolve. This speaks to a problematic approval process that, unfortunately, doesn't critically evaluate data -- but only serves to manage public perception.
As a parent of a covid recovered child, I am especially concerned about the potential vaccine mandate for all children in public & private schools in NY (an assembly bill A08378 has been introduced) I have been following your substack closely and wondering if any studies of Covid recovered & vaccinated children are in progress and when might we have more information? I feel at this point in time, I can’t in good conscience allow my child to be vaccinated without any AE data.
Hi there - generally in the same boat as you; I do not know of anything specific, but as with the adult population, I would expect they are doing real-world surveillance and some initial studies will come out in the next month or two. Agree we need much more AE data, and longer follow-up. Best-
Really well done! AS you say, this data should not be left out due to oversight. this category is HUGE. One might even argue central.
Thank you for reading. Hopefully, this helps to achieve some transparency!
You state you are a physician and hope that vaccinated someone previously infected will result in better immunity. Has there ever been a vaccine developed that has been used in those who have already recovered from the same disease? I am not a physician but it is my understanding that vaccines have always been used to provide immunity to those who have not had the disease. The EUA for these vaccines was for active immunization for the prevention of COVID-19 caused by SARS-CoV-2. Only after that narrative failed did the CDC begin to say its real purpose was to prevent severe covid. I would have thought the EUA should have been rescinded.
Well, Shingrix is commonly recommended for those who recovered from Shingles although the trials specifically EXCLUDED that group of people.
But the more relevant question is are there examples of respiratory viruses where we commonly vaccinate the recovered. I cant think of one.
Thank you for your comment and for reading. Nothing in medicine is absolute . . . and so I am certain there are examples, and I don't purport to know vast expanse of vaccinology. That being said I agree with you that the case for the initial EUA is different than the current rationale, and continues to evolve. This speaks to a problematic approval process that, unfortunately, doesn't critically evaluate data -- but only serves to manage public perception.
Omission of data and statistics has happened before, also for a flu drug...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375804/
Thank you for the link. Riveting reading! Even though this was published in 2015, there seems to be many parallels to today!